18 September 2021News The research aimed at improving the process of production of mini-tablets was initiated by the IMA Group, which produces not just equipment, but completed integrated systems for integrated management in the pharmaceutical industry. To do this, she studies the production of mini-tablets by direct compression, looking at how the rotary press tablet affects the operating and formula parameters. Why mini-pills? They are several single dosage forms, representing all the advantages of these systems over single dosage forms: low risk of dose overturning, high degree of dispersion in the gastrointestinal tract and reproducible bioavailability. Moreover, if they are made by direct pressing instead of granulation or extrusion and spheronization, production is one step and leads to lower costs and increased production efficiency. Therefore, the aim of the study was first to determine the best production parameters (stamp feed rate, turret speed, pre-compression force, range of possible compression forces) for the production of mini-tablets with technological characteristics according to the European Pharmacopoeia (homogeneity, crushing strength), looseness). Subsequently, the effect of different types of cellulose, molecular weight, particle size and number at two different compressive forces on technological characteristics (crushing strength, crumbliness) and theophylline release was evaluated. The researchers concluded that both cellulose derivatives allow the production of matrix mini-tablets containing TH by direct compression. Based on the dissolution profiles, it is obvious that a more constant and controlled release can be achieved with a hydrophilic polymer (HPMC), which releases the drug by swelling, rather than a hydrophobic, diffusion-controlled drug. Read more: www.epmmagazine.com